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Effects of Intravenous Ketamine Infusions in a Neuropathic Pain Patient with Lichen Sclerosus et Atrophicus
Adam J. Smith,Ashraf F. Hanna,Josh S. Armstrong
- , 2016, DOI: 10.1159/000446528
Abstract: A patient reported to the Florida Spine Institute (Clearwater, Fla., USA) with severe lichen sclerosus of the anogenital region and legs. The patient's pain presentation was neuropathic with hypersensitivity, allodynia, swelling, and weakness. The patient had failed multiple pain management modalities including opioid therapy, anticonvulsants, and antidepressants. The patient completed a standard intravenous ketamine infusion regimen developed at the Florida Spine Institute and reported complete abolishment of her pain syndrome. For the first time, we report that ketamine infusions also dramatically improved a patient's lichen sclerosus. That ketamine is known to have immunomodulatory properties, and given the clinical observations described in this case report, suggests that ketamine should be explored as a possible new therapeutic option for managing lichen sclerosus, especially in cases that are refractory to conventional therapies
Successful disease-specific induced pluripotent stem cell generation from patients with kidney transplantation
Tayaramma Thatava, Adam S Armstrong, Josep De Lamo, Ramakrishna Edukulla, Yulia Khan, Toshie Sakuma, Seiga Ohmine, Jamie L Sundsbak, Peter C Harris, Yogish C Kudva, Yasuhiro Ikeda
Stem Cell Research & Therapy , 2011, DOI: 10.1186/scrt89
Abstract: The feasibility of iPS cell generation from patients with a history of ESRD was investigated using lentiviral vectors expressing pluripotency-associated factors.In the present article we report, for the first time, generation of iPS cells from kidney transplant recipients with a history of autosomal-dominant polycystic kidney disease (ADPKD), systemic lupus erythematosus, or Wilms tumor and ESRD. Lentiviral transduction of OCT4, SOX2, KLF4 and c-MYC, under feeder-free conditions, resulted in reprogramming of skin-derived keratinocytes. Keratinocyte-derived iPS cells exhibited properties of human embryonic stem cells, including morphology, growth properties, expression of pluripotency genes and surface markers, spontaneous differentiation and teratoma formation. All iPS cell clones from the ADPKD patient retained the conserved W3842X mutation in exon 41 of the PKD1 gene.Our results demonstrate successful iPS cell generation from patients with a history of ESRD, PKD1 gene mutation, or chronic immunosuppression. iPS cells from autosomal kidney diseases, such as ADPKD, would provide unique opportunities to study patient-specific disease pathogenesis in vitro.The prevalence of chronic kidney disease and end-stage renal disease (ESRD) is increasing worldwide [1]. Simultaneously, the total Medicare cost of ESRD has risen from $12.2 billion in 2000 to $39.5 billion in 2010 [1]. ESRD is incurable, requiring hemodialysis or preferably renal transplantation. These therapies are associated with considerable limitations, however, including the shortage of available donor organs and a lifelong immunosuppressive regimen [2]. Moreover, despite significant improvement in 1-year kidney allograft survival, the rate of chronic graft loss after the first year remains substantial [3].The most common causes of ESRD in the United States are diabetes and hypertension [4], while the incidence of nondiabetic ESRD, such as glomerular diseases and cystic diseases, are increasing. Autosomal-domi
Rickettsia australis and Queensland Tick Typhus: A Rickettsial Spotted Fever Group Infection in Australia
Adam Stewart,Mark Armstrong,Stephen Graves
- , 2017, DOI: 10.4269/ajtmh.16-0915
Abstract:
Ditch water levels manages for environmental aims: effects on field soil water regimes
A. Armstrong,S. Rose
Hydrology and Earth System Sciences (HESS) & Discussions (HESSD) , 1999,
Abstract: The effects of ditch water management regimes on water tables are examined for two test sites in England, Halvergate in the Broads and Southlake Moor in the Somerset Levels and Moors Environmentally Sensitive Areas. It is observed that in some fields the effects of water management are only poorly transferred from the ditch to the field centre, especially where the hydraulic conductivity of the subsoil is small. Where there are large variations in the ditch water levels, reflecting the influence of major ditches subject to pump drainage, field soil water regimes differ significantly. Nevertheless, the effects of even quite small changes in the ditch regime cam be noticeable. Simple modelling studies show that much greater effects can be achieved by increasing the frequency of ditches within wetlands.
Einstein metrics with anisotropic boundary behaviour
S. Armstrong,O. Biquard
Mathematics , 2009,
Abstract: We construct new examples of complete Einstein metrics on balls. At each point of the boundary at infinity, the metric is asymptotic to a homogeneous Einstein metric on a solvable group, which varies with the point at infinity.
An unusual haemorrhagic complication of an anastomotic leak and a novel method of controlling the haemorrhage
A Armstrong,S Martin
- , 2017, DOI: 10.1308/rcsann.2016.0321
Abstract: Restorative proctocolectomy (RP) is undertaken for patients with familial adenomatous polyposis (FAP) and ulcerative colitis, but is associated with a risk of anastomotic leak
Genetic Identification of a Network of Factors that Functionally Interact with the Nucleosome Remodeling ATPase ISWI
Giosalba Burgio,Gaspare La Rocca,Anna Sala,Walter Arancio,Dario Di Gesù,Marianna Collesano,Adam S. Sperling,Jennifer A. Armstrong,Simon J. van Heeringen,Colin Logie,John W. Tamkun,Davide F. V. Corona
PLOS Genetics , 2008, DOI: 10.1371/journal.pgen.1000089
Abstract: Nucleosome remodeling and covalent modifications of histones play fundamental roles in chromatin structure and function. However, much remains to be learned about how the action of ATP-dependent chromatin remodeling factors and histone-modifying enzymes is coordinated to modulate chromatin organization and transcription. The evolutionarily conserved ATP-dependent chromatin-remodeling factor ISWI plays essential roles in chromosome organization, DNA replication, and transcription regulation. To gain insight into regulation and mechanism of action of ISWI, we conducted an unbiased genetic screen to identify factors with which it interacts in vivo. We found that ISWI interacts with a network of factors that escaped detection in previous biochemical analyses, including the Sin3A gene. The Sin3A protein and the histone deacetylase Rpd3 are part of a conserved histone deacetylase complex involved in transcriptional repression. ISWI and the Sin3A/Rpd3 complex co-localize at specific chromosome domains. Loss of ISWI activity causes a reduction in the binding of the Sin3A/Rpd3 complex to chromatin. Biochemical analysis showed that the ISWI physically interacts with the histone deacetylase activity of the Sin3A/Rpd3 complex. Consistent with these findings, the acetylation of histone H4 is altered when ISWI activity is perturbed in vivo. These findings suggest that ISWI associates with the Sin3A/Rpd3 complex to support its function in vivo.
D-Dimer Levels before HIV Seroconversion Remain Elevated Even after Viral Suppression and Are Associated with an Increased Risk of Non-AIDS Events
Adam Armstrong,Amy C. Justice,Anuradha Ganesan,Brian K. Agan,David Rimland,Infectious Disease Clinical Research Program HIV Working Group,Ionut Bebu,Jason Okulicz,Kaku So-Armah,Matthew S. Freiberg,Russell Tracy,Thomas O’Bryan
- , 2016, DOI: 10.1371/journal.pone.0152588
Abstract:
Resistance in Barley (Hordeum vulgare L.) to New Invasive Aphid, Hedgehog Grain Aphid (Sipha maydis, Passerini) (Hemiptera: Aphididae)  [PDF]
D. W. Mornhinweg, G. J. Puterka, J. S. Armstrong
American Journal of Plant Sciences (AJPS) , 2020, DOI: 10.4236/ajps.2020.116063
Abstract:
Sipha maydis Passerini (Hemiptera: Aphididae) is a pest of cereals in many regions of the world and was identified as an invasive pest of the US in 2007. Regional surveys from 2015-2017 revealed this pest was broadly distributed throughout many of the western Great Plains states where it is a potential threat to cereal production. The common name hedgehog grain aphid, HGA, has been associated with Sipha maydis in the US. Cross-resistance where a plant is resistant to one aphid species and is also resistant to another species that is known to occur. Six barleys were evaluated for cross-resistance to HGA: Russian wheat aphid, RWA, resistant germplasms STARS 9301B and STARS 9577B and cultivar “Mesa”; greenbug, GB, resistant germplasm STARS 1501B and cultivar “Post 90”; and RWA and GB resistant experimental line 00BX 11-115. Cultivars “Morex” and “Schuyler” were susceptible controls. Antixenosis was measured 5 days after infestation by HGA. Seedling damage ratings and reductions in seedling growth were recorded after 17 days of infestation. Intrinsic rate of increase, rm, of HGA was determined by following the development of newborn aphids to adulthood and reproduction. 00BX 11-115 and Post 90 had significantly greater antixenosis (fewer aphids/seedling), significantly lower plant damage ratings, and significantly lower intrinsic rates of increase than other entries. Differences in seedling growth were not significant. 00BX 11-115 and Post 90 were the only entries with the Rsg1 greenbug resistance gene. Rsg1 greenbug resistance confers cross-resistance to HGA in the seedling stage.
Provenance of sands from Cazones, Acapulco, and Bahía Kino beaches, Mexico
Armstrong-Altrin, John S.;
Revista mexicana de ciencias geológicas , 2009,
Abstract: petrographic, major, trace, and rare-earth element geochemistry of sands from three beaches of méxico (cazones, acapulco, and bahía kino) were studied to determine their provenance. the textural study reveals that the proportion of quartz is higher in bahía kino (~48-83 %) than in cazones (~22-48 %) and acapuclo (~20-48 %) sands. most of the sand samples are classified as felsic sands using sio2 content. the variations in sio2, fe2o3, mgo, tio2 contents and al2o3 / tio2, k2o/ na2o, sio2/ al2o3 ratios among the three study areas reflect differences in source rock characteristics. the low chemical index of alteration values (cia: ~38-58) suggest the prevalence of week weathering conditions in the source regions. a steady weathering trend identified in the a-cn-k diagram for acapulco and cazones sands is indicative of uplift along the source region and indicates that sands were derived from diverse sources. a major variation in ∑ree content is observed in acapulco sands (~22-390 ppm) than in cazones (~49-83 ppm) and bahía kino sands (~50-89 ppm), and is likely due to differences in fractionation of minerals. however, all the sand samples show similar ree patterns with enriched lree, depleted hree and a negative eu anomaly. the comparison of ree data of sands with those of source rocks located relatively close to the study areas suggest that cazones and acapulco sands were derived from felsic and intermediate rocks, whereas bahía kino sands were derived from felsic rocks.
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